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Speeding Drug Development through Impurity Control Strategies
 
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Dr. Steven Baertschi delivered this talk in South San Francisco, CA on October 31, 2018. Development and implementation of impurity control strategies is a complicated, yet critical process necessary to ensure overall pharmaceutical product quality and patient safety. Existing guidelines for control of new impurities in drug substances and new drug products (ICH Q3A/Q3B, USP Chapters 476 & 1086) apply to commercial products or products in late-stage clinical development (Phase 3). In addition, guidance for mutagenic impurities (ICH M7), which covers early clinical development through commercialization, is a relatively new guideline and questions regarding its implementation remain. The lack of regulatory guidance regarding impurity controls at early stages of clinical development (prior to Phase 3) provides both questions and opportunities for the development of effective control strategies. This talk focuses on risk-based, chemistry-driven approaches to speeding the development of organic impurity control strategies throughout clinical development. Relevant examples and references are provided.
Effect of Packaging on Stability of Drugs and Drug Products
 
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Pecha Kucha for Quality Assurance Assignment
Views: 3907 yousra mustafa
Development and Delivery of Pharmaceutical Products  (CMC) - MaRS Best Practices
 
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Moving from drug discovery to drug development requires a particular skillset usually not yet honed by start-ups. This phase of the development process is highly regulated and critical. Let Dr. Colin Minchom take you through the aspects of the Chemistry, Manufacturing and Control (CMC) portion of the drug development process. Watch this video to learn about the pharmaceutical product development which includes objectives of formulation, cost-effective strategies to reach key milestones and more. MaRS -- Building Canada's next generation of global technology companies. marsdd.com
The FDA Drug Development Process: GLP, GMP and GCP Regulations
 
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This Video provides an overview of the FDA's Drug Development Process. This webinar also includes the major FDA regulations involved in the Drug Development Process - the GLP, GMP and GCP regulations. This Video is ideal for those who are new to the Drug Development process and those experienced researchers that need an update on FDA requirements. This webinar will address the basic Drug Development Process, nonclinical trials and human clinical trials. In addition the two major FDA submissions during Drug Development will be covered - the IND submission and the NDA submission. For More Information Contact - Organization: NetZealous BDA GlobalCompliancePanel Website: http://www.globalcompliancepanel.com/ Email: [email protected] Help us caption & translate this video! http://amara.org/v/JGhy/
Views: 27950 GlobalCompliance Panel
WEBINAR: Specifications for Small Molecule Drug Products
 
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Led by Dr Mark Powell, a Fellow of the Royal Society of Chemistry (RSC) with over 25 years’ experience as a senior analytical chemist. In 2013, Mark set up Mark Powell Scientific, a company that offers training and consultancy services in analytical chemistry. This webinar will cover: • Regulatory guidance (ICH, FDA, EMA) • Tests appropriate to different dosage forms • Dissolution specifications for immediate-release, modified-release and extended-release drug products • Dissolution specifications in the context of the biopharmaceutical classification system • Control of polymorphism, enantiomeric purity, drug-related impurities and microbiological contamination • Specifications for combination drug products • The role of specifications in maximizing drug product stability
Phases of Pharmaceutical Industry
 
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The video-clip 'Phases of pharmaceutical industry' presents, step by step, the medicine line production. A 2D animation presents both the individual phases and the overall picture of the process. The students familiarize with the requirements and the conditions of medicine production, the required technology and the importance of health and safety specifications. What follows is the acquaintance with the methods of product qualitative control, the role of the head pf production and issues of waste management. The clip is instructional as far as medicine production is concerned and can be used as an introduction to the topic 'Industries' and 'Pharmacy'.
Views: 212667 EducationalTVGreece
pharmaceutical cartoning machine for drug box packaging system with frequency control
 
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pharmaceutical cartoning machine for drug box packaging system with frequency control Introduction: It is a continuous motion Carton Boxes Packing Machine,which is suitable for the packaging of snack, bottles, vials, noodle,pillow packs, etc.The machine finished running by a series of photo-electro controller to make the machine stability and guarantee the packing quality. It includes cantons in suction and open, products put into, printing batch number, sealing or option hot-glue device. The machine can be single used or linked with Filling Machine, Blister Packing Machine, Shrink Machine, Three Dimensional Packaging Machine to form a production chain. Feature: 1.International famous brand of electrical component such as PLC touch screen, frequency inverters,etc. 2.Adopt human-machine operation system. 3.Automatically displaying device for trouble, speed and finished products counting. 4.Machine running without pressing if no products or incorrect position of products. And stopping automatically if incorrect position of product into carton after return or no cartons or out of leaflets continuous. 5.No products not suction leaflet, no leaflet not suction carton . 6.Automatic detection and rejection device for lacking blister goods and leaflets. 7.Protecting automatically for overloading. 8.stable performance , operation is easy . Main Function: Automatic folding(1-4 folding) and conveying of manual leaflet, automatic maternal categorizing and feeding; automatic paper carton spreading; automatic manual leaflet and material carton packaging, synchronous (3-row) batch number printing, automatic paper carton sealing, automatic waster eliminating. Main technical parameters: Encasing speed 50-120 boxes/min Box Quality requirement 250-350g/m2 Dimension range L×W×H (40-250)mm×(20-170)mm×(15-90)mm Quality requirement 60-70g/m2 Compressed air Working pressure ≥0.6Mpa Air consumption 120-160L/min Power 220V/50Hz Motor power 1.5kw Machine dimension(L×W×H) 3100mm×1100mm×1850mm About Packing: To ensure our service quality, we will execute the following packaging standards in delivery: 1.All the products before delivery should be tested by assemble and debugging engineer, wiped up and cleaned, then wrapped by stretch film to protect it from moist. The precision part need to flexible package. 2.In addition, without standard tools, manual and other documents, and allow ex-factory confirmation sheet, the machine cannot leave factory All the products will be packed in wooden case. The exported products use plywood case to pack. The foot margin of equipment fixed tightly to make the machine can experience loading and uploading, the upward mark will be posted on the wooden case. Our services: A-The whole system The Seller ensure the whole system can get to the requested capacity, accept and cooperate with the Buyer to pass the final testing of the whole system. B-On-site installation: The Seller supply the on site installation for the whole system, but the fees including air tickets, foods, hotel and translator in this period should be paid by User,the subsidy is 50USD/day. C-Technical support: The Seller supplies the technical support of the whole use life of the system,including the capping machine,and the procedures. D-Spare parts supply: The Seller should supply the quick-wear parts with the machine, to help the Buyer n further using. In the quality guarantee period, the Seller will supply the broken parts for free, except the easy worn parts or the damage is caused by misoperation.After the guarantee period, the Seller will supply all the parts that the User need for the whole use life of the machine in cost price.
Views: 2264 Tracy
Pharmaceutical interview questions on ICH stability guidelines|Part-1
 
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What is Significant Change in Pharmaceutical Stability Testing? Or Can you explain what do you mean by significant changes? This is the one of the frequently asked question in the interview. In this tutorial you will learn how to define “Significant change” in a drug product or drug substances, according to ICH Q-1E guideline.
Views: 7348 Pharma Learners
Advanced Pharmaceutical Manufacturing
 
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There are a number of challenges that the industry faces in order to transition towards more competitive, systematic and efficient manufacturing. Regulatory authorities have recognized the deficiencies of pharmaceutical product manufacturing and aim to enhance process understanding through Quality by Design (QbD) and Process Analytical Technology (PAT) tools. As a result of this current effort to change the mindset in order to mimic the rest of the chemical industry, an additional transition is becoming more and more appealing: transition from batch to continuous production mode. However, continuous manufacturing requires detailed process understanding in terms of the evolution of all critical material properties as a function of its operating parameters and environmental conditions. Once process knowledge is translated into models, computer aided dynamic simulation tools will allow the design, analysis and optimization of continuous integrated processes. In this talk I will discuss the work that has been done in my lab towards the development of an integrated platform that will enable the efficient flowsheet simulation and analysis, the assessment of design alternatives, the feasibility analysis of the production line, and the control and optimization of process design and operations. The developed flowsheet model includes modules for all the necessary unit operations, namely powder feeding, mixing, roller compaction, tablet press and milling integrated to represent a tablet manufacturing line. Models used to represent each unit operation vary from empirical, first-principle or hybrid. Population balance models are developed in order to track the composition and particle size changes throughout complex powder processes dynamically. The developed flowsheet simulation is used to predict the propagation of upstream disturbances to final product quality, the assessment of recycle stream benefits, the identification of process integration bottlenecks and evaluation of different control strategies in order to retain the process within its design space. In addition, global dynamic sensitivity analysis is performed to identify critical process parameters not only within each unit operation, but also between different processes. Finally, simulation based optimization techniques enable the identification of the optimal operating conditions, as well as the optimal design sequence which leads to pharmaceutical tablets with desired characteristics. This work aims to merge knowledge, experience, experimental results and modeling tools for developing a dynamic simulation platform that will enable the safe implementation of the transition towards continuous pharmaceutical manufacturing. Biography: Marianthi Ierapetritou is a Professor and Chair in the Department of Chemical and Biochemical Engineering at Rutgers University in Piscataway, New Jersey. Dr. Ierapetritou’s research focuses on the following areas: 1) process operations; (2) design and synthesis of flexible production systems focusing on pharmaceutical manufacturing; 3) modeling of reactive flow processes; and 4) metabolic engineering with focus on biopharmaceutical production. Her research is supported by several federal (NIH, NSF, ONR, NASA) and industrial (BMS, J&J, ExxonMobil, Honeywell, Cardinal Health) grants. Among her accomplishments are the Outstanding Faculty Award, the Rutgers Board of Trustees Research Fellowship for Scholarly Excellence, and the prestigious NSF CAREER award. She has more than 180 publications, and has been an invited speaker to numerous national and international conferences. Dr. Ierapetritou obtained her BS from The National Technical University in Athens, Greece, her PhD from Imperial College (London, UK) in 1995 and subsequently completed her post-doctoral research at Princeton University (Princeton, NJ) before joining Rutgers University in 1998.
Views: 45354 APMonitor.com
Effect of Packaging on Stability of Drugs and Drug Products
 
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Pharmaceutical sciences #pharmaceutics
Container-Closure Integrity Testing for Drug Delivery Devices
 
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Container-closure integrity is evaluated during all phases of the product-package life cycle for a drug delivery device from package development, as part of the design verification study, to manufacturing, through commercial stability, and in many cases in lieu of sterility testing. So, what exactly is meant by the term container-closure integrity, and how can an appropriate leak testing technology be selected for a drug delivery device such as a pre-filled syringe, a cartridge, an auto-injector, or a pen injector? This presentation will compare various container-closure integrity testing technologies, will explore the applications of these technologies at different phases of the product-package life cycle, and will discuss method development and validation strategies to ensure the sterility and quality of the drug product while packaged in the drug delivery device through to expiry.
What is PROCESS VALIDATION? What does PROCESS VALIDATION mean? PROCESS VALIDATION meaning
 
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✪✪✪✪✪ WORK FROM HOME! Looking for WORKERS for simple Internet data entry JOBS. $15-20 per hour. SIGN UP here - http://jobs.theaudiopedia.com ✪✪✪✪✪ ✪✪✪✪✪ The Audiopedia Android application, INSTALL NOW - https://play.google.com/store/apps/details?id=com.wTheAudiopedia_8069473 ✪✪✪✪✪ What is PROCESS VALIDATION? What does PROCESS VALIDATION mean? PROCESS VALIDATION meaning - PROCESS VALIDATION definition - PROCESS VALIDATION explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6UuCPh7GrXznZi0Hz2YQnQ Process Validation is the analysis of data gathered throughout the design and manufacturing of a product in order to confirm that the process can reliably output products of a determined standard. Regulatory authorities like EMA and FDA have published guidelines relating to process validation. The purpose of process validation is to ensure varied inputs lead to consistent and high quality outputs. Process validation is an ongoing process that must be frequently adapted as manufacturing feedback is gathered. End-to-end validation of production processes is essential in determining product quality because quality cannot always be determined by finished-product inspection. Process validation can be broken down into 3 steps: process design, process qualification, and continued process verification. Design of experiments is used to discover possible relationships and sources of variation as quickly as possible. A cost benefit analysis should be conducted to determine if such an operation is necessary. Quality by Design is an approach to pharmaceutical manufacturing that stresses quality should be built into products rather than tested into products; that product quality should be considered at the earliest possible stage rather than at the end of the manufacturing process. Input variables are isolated in order to identify the root cause of potential quality issues and the manufacturing process is adapted accordingly. Process Analytical Technology is used to measure critical process parameters (CPP) and critical quality attributes (CQA). PAT facilitates measurement of quantitative production variables in real time and allows access to relevant manufacturing feedback. PAT can also be used in the design process to generate a process qualification. Critical Process Parameters Operating parameters that are considered essential to maintaining product output within specified quality target guidelines. Critical Quality Attributes (CQA) are chemical, physical, biological and microbiological attributes that can be defined, measured, and continually monitored to ensure final product outputs remain within acceptable quality limits. CQA are an essential aspect of a manufacturing control strategy and should be identified in stage 1 of Process Validation: Process design. During this stage acceptable limits, baselines, and data collection and measurement protocols should be established. Data from the design process and data collected during production should be kept by the manufacturer and used to evaluated product quality and process control. Historical data can also help manufacturers better understand operational process and input variables as well as better identify true deviations from quality standards compared to false positives. Should a serious product quality issue arise, historical data would be essential in identifying the sources of errors and implementing corrective measures. Design Space Verification confirms that quality can be guaranteed within an identified range of input and operating variables. Continued Process Verification is the ongoing monitoring of all aspects of the production cycle. It aims to ensure that all levels of production are controlled and regulated. Deviations from prescribed output methods and final product irregularities are flagged by a process analytics database system. The FDA requires production data be recorded (FDA requirements (§ 211.180(e)). Continued process verification is stage 3 of process validation. The European Medicines Agency defines a similar process known as Ongoing Process Verification. This alternative method of process validation is recommended by the EMA for validating processes on a continuous basis. Continuous Process Verification analyses Critical Process Parameters and Critical Quality Attributes in real time to confirm production remain within acceptable levels and meet standards set by ICH Q8, Pharmaceutical Quality Systems, and Good manufacturing practice.
Views: 12112 The Audiopedia
What is GOOD MANUFACTURING PRACTICE? What does GOOD MANUFACTURING PRACTICE mean?
 
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✪✪✪✪✪ Download DENTCOIN mobile application - https://dent.app.link/DMolgDMqRT and get FREE 599 Dentcoins, most practical cryptocurrency on the market, which you can use to top up your mobile data plans in 40+ countries around the world. Visit: https://dent.app.link/DMolgDMqRT and click on Dent App on the top to chose iPhone or Android version. ✪✪✪✪✪ ✪✪✪✪✪ The Audiopedia Android application, INSTALL NOW - https://play.google.com/store/apps/details?id=com.wTheAudiopedia_8069473 ✪✪✪✪✪ What is GOOD MANUFACTURING PRACTICE? What does GOOD MANUFACTURING PRACTICE mean? GOOD MANUFACTURING PRACTICE meaning - GOOD MANUFACTURING PRACTICE definition - GOOD MANUFACTURING PRACTICE explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6UuCPh7GrXznZi0Hz2YQnQ Good manufacturing practices (GMP) are the practices required in order to conform to the guidelines recommended by agencies that control authorization and licensing for manufacture and sale of food, drug products, and active pharmaceutical products. These guidelines provide minimum requirements that a pharmaceutical or a food product manufacturer must meet to assure that the products are of high quality and do not pose any risk to the consumer or public. Good manufacturing practices, along with good agricultural practices, good laboratory practices and good clinical practices, are overseen by regulatory agencies in the United States, Canada, Europe, China, and other countries. Good manufacturing practice guidelines provide guidance for manufacturing, testing, and quality assurance in order to ensure that a food or drug product is safe for human consumption. Many countries have legislated that food and pharmaceutical and medical device manufacturers follow GMP procedures and create their own GMP guidelines that correspond with their legislation. All guidelines follow a few basic principles: Manufacturing facilities must maintain a clean and hygienic manufacturing area. Controlled environmental conditions in order to prevent cross contamination of food or drug product from adulterants that may render the product unsafe for human consumption. Manufacturing processes are clearly defined and controlled. All critical processes are validated to ensure consistency and compliance with specifications. Manufacturing processes are controlled, and any changes to the process are evaluated. Changes that affect the quality of the drug are validated as necessary. Instructions and procedures are written in clear and unambiguous language. (Good Documentation Practices) Operators are trained to carry out and document procedures. Cross contamination with unlabelled major allergens is prevented. Records are made, manually or by instruments, during manufacture that demonstrate that all the steps required by the defined procedures and instructions were in fact taken and that the quantity and quality of the food or drug was as expected. Deviations are investigated and documented. Records of manufacture (including distribution) that enable the complete history of a batch to be traced are retained in a comprehensible and accessible form. The distribution of the food or drugs minimizes any risk to their quality. A system is available for recalling any batch from sale or supply. Complaints about marketed products are examined, the causes of quality defects are investigated, and appropriate measures are taken with respect to the defective products and to prevent recurrence. Practices are recommended with the goal of safeguarding the health of consumers and patients as well as producing good quality food, medicine, medical devices, or active pharmaceutical products. In the United States, a food or drug may be deemed "adulterated" if it has passed all of the specifications tests, but is found to be manufactured in a facility or condition which violates or does not comply with current good manufacturing guideline. Therefore, complying with GMP is mandatory in all pharmaceutical manufacturing, and most food processing....
Views: 31168 The Audiopedia
FDA Approves Contrave Weight Control Drug
 
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Dr. Jennifer Ashton explains how the new drug works and the possible health risks.
Views: 5637 ABC News
Treat yourself like a drug, control the dosage
 
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Discover the secret technique to make any man chase (audiobook): mindfulattraction.org Purchase my course "The Psychological Game of Attraction": https://dalexis-school.thinkific.com WORK WITH ME 1-1: https://mindfulattraction.org/inner-game-coaching/ Purchase seminars & books: https://mindfulattraction.org/new-products-1/
Views: 10079 Mindful Attraction 2.0
What's in an IND? Guide to Writing IND For Biologics
 
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This talk was presented by Dr. Zahra Shahrokh, a NINDS consultant at STC Biologics. Dr. Shahrokh addresses the requirements to file an Investigational Drug Application for a biologic therapy and describes the different sections of the IND with a focus on therapeutic proteins. The presentation ends by providing examples of common deficiencies and mis-steps that Sponsors are likely to make.
Views: 5611 NIHNINDS
Inside the Indian Generic Drug Manufacturer Cipla
 
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India produces over 30% of the world's entire supply of generic drugs. Cipla is one of India's largest drug manufacturers. It supplies antiretroviral drugs to about one third of AIDS patients under treatment in Africa. C&EN Senior Correspondent Jean-François Tremblay went inside Cipla's advanced pharmaceutical ingredient manufacturing plant to learn more about the stringent regulations it must follow. India's future as the world's drugstore is a controversial topic. Other drugmakers have been heavily fined, or had products recalled or banned, because of problems at plants. And India is under pressure to make its patent system more like those in western nations. But India has found a market for low-cost drugs and that market isn't about to disappear. More at http://cenm.ag/cpla Like C&EN? Want more chemistry video goodness? Subscribe to our YouTube channel: https://www.youtube.com/user/CENonline Subscribe to C&EN to watch science videos with a focus on chemistry, and to hear from the researchers behind it all. -- Looking for C&EN elsewhere on the internet? Homepage: http://cen.acs.org Facebook: http://www.facebook.com/CENews Twitter: http://www.twitter.com/cenmag Tumblr: http://cenwatchglass.tumblr.com
Views: 87725 CEN Online
Attempts to control drug trafficking from Morocco to Algeria
 
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(24 May 2017) LEADIN: The district of Tlemcen in Algeria is still battling drug trafficking from Morocco. It comes despite extreme measures such as the digging of a 250 kilometre trench between the two countries. STORYLINE: A closed border between Algeria and Morocco and a point of ongoing contention between the two countries. Moroccan officials frequently demand Algeria open its borders to them. But Algeria refuses, arguing the problem of drug trafficking from its western neighbour justifies the extra security. Algeria shares more than 1,500 kilometres (932 miles) of borders with Morocco, but despite keeping its borders closed since 1994, significant amounts of drugs still cross the from Morocco to Algeria. "The main goal of these checkpoints is to control vehicles and people in order to fight smuggling and especially drugs. It allows us to get good results," says Malik Abdelhamid, Head of Customs for the Sebdou region. Over the last decade, images of huge drugs seizures became commonplace on Algerian TV. Algerian authorities responded to the out of control situation at the borders by digging a trench from the north east of Morocco to the north west of Algeria. "It's been two years since the trench between Algeria and Morocco was dug, more than 250 kilometres (155 miles) long," says Mohamed Benaroum, Head of Customs for Maghnia. "It gave good results against smuggling and drug trafficking. We noticed a huge decline in product smuggling from and to Algeria, especially drugs which was widespread (before)." But the district of Tlemcen is the region that still suffers the most. All of its 53 cities, towns and villages have well organised security coverage with police, border guards and customs involved in operations. But that's still not enough. Despite an overall drop in drugs crossing over, traffickers are now finding new innovative ways to reach Morocco, such as donkeys to cross the mountains or jet skis to get to the beach. "The traffickers have now started using other ways, they don't transfer big quantities anymore," explains Toufik Moualek, Head of External Relationships for the Tlemcen customs unit. "During the the first four months of April we performed 72 drug related operations. It's not that big but (we seized) a quantity of more than three tonnes and we have arrested 59 people." Customs play a huge role in the seizing of trafficked drugs. Jamel Brika is their Head of Communications and says that last year they seized products with a value of 490,000,000 Algerian Dinar (4,500,000 US Dollars). You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/875bd3caca45702a97b8f488755c692e Find out more about AP Archive: http://www.aparchive.com/HowWeWork
Views: 6696 AP Archive
Trends & Best Practices in Global Drug Product Labeling Management
 
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Click here to register for free and to view the entire webinar: http://xtalks.com/Practices-Global-Drug-Product-Labeling-Management.ashx?utm_source=YouTube&utm_medium=Teaser&utm_campaign=XT0776_Sciformix Speakers: Bindu Narang, Director of Scientific Writing and Regulatory Affairs, Sciformix Boris Jankowski, Director of Solutions Architecture, Sciformix Craig Trautman, CEO, Intagras Drug product labeling is continuing to grow both in complexity and strategic importance as the key document for communication of benefit: risk to health care professionals and patients. Life science companies not only have to ensure harmony of messaging from Core Data Sheet to Local Prescribing Information, but also track and document the implementation of labeling changes and any local variations. In addition, there is increasing pressure by Health Authorities to demonstrate overall performance, quality and compliance of the end-to-end labeling process. To address these challenges, a unified global labeling continuum that coordinates upstream (i.e. signal detection) and downstream (i.e. the printing and distribution of the label) activities requires an integrated services, process and technology model. This webinar will focus on translating current business drivers and challenges within the global drug product labeling domain into a set of opportunities and next-generation operating models that support scale, efficiency, quality and compliance. Viewers will learn: What is driving labeling complexity in terms of internal pressures, such as global expansion and evolving global health authority expectations What the future looks like with regards to the seamless integration of the end-to-end labeling process (from signal to package) coupled with external services and technology enablers How to assess the overall performance and quality of the labeling process
Views: 269 Xtalks Webinars
5 Prescription Drugs That Destroy Your Health
 
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You’re probably thinking that there is no way the pharmaceutical industry would sell harmful products. Unfortunately, you would be naïve if you thought that. The pharmaceutical industry is one of the most powerful industries in the world. They have sole control over what drugs and medications are released and sold to the public. #PrescriptionDrugs #Health #SideEffects Music: https://www.youtube.com/audiolibrary/music Summary: High Cholesterol. If you have high cholesterol, you should be concerned about what you’re eating, not the drugs you’re taking. Add olive oil, oats and garlic to your diet. They help reduce inflammation and can even lower your bad LDL cholesterol. They can also increase your good HDL cholesterol. Acid Reflux. If you have bad acid reflux, try using an herbal relief instead of pharmaceutical drugs. One example would be elm lozenges. You can find these at your local health food store. What they do is coat the throat and the stomach with antioxidants that relieve inflammation in the intestines. They also help protect the gastrointestinal tract from any excess acid. There is always an alternative to pharmaceutical drugs, you just have to find it! Now that you've reached the end, here's some more information about dementia and Alzheimer's and how certain prescription drugs may affect these symptoms. According to Alzheimer’s Disease International, every three seconds, someone in the world develops dementia and right now there are close to 50 million people around the world suffering from some form of dementia. According to a report by Harvard Health Publishing, a few studies have also shown that drugs like benzodiazepines (medications for sleep disorders and anxiety) have been linked with an increased risk of dementia in patients who take these medications over a long-term period. Benzodiazepines: One study, published on September 9, 2014, in the journal BMJ, found that Benzodiazepine use was linked to a higher risk of Alzheimer’s disease. They found that those who had taken Benzodiazepines for three to six months had a 32% greater risk of developing Alzheimer’s. They also found that those who had taken Benzodiazepines for longer than 6 months had an 84% greater risk than those who had not taken one. Another Harvard study went on to say that ‘medications are common culprits in mental decline. With aging, the liver becomes less efficient at metabolizing drugs, and the kidneys eliminate them from the body more slowly. As a result, drugs tend to accumulate in the body. Elderly people in poor health and those taking several different medications are especially vulnerable.’ The medications listed by this study include antidepressants, antihistamines, narcotics, and sedatives. The myth about vaccines: While there have been many rumors and myths surrounding vaccines that cause dementia, it is simply not true and that myth has been thoroughly debunked by numerous studies. The United States National Library of Medicine and the National Institutes of Health performed a study on more than 4,392 eligible subjects that resulted in the conclusion that: ‘past exposure to vaccines against diphtheria or tetanus, poliomyelitis and influenza may protect against subsequent development of Alzheimer’s disease.’ So instead of vaccines causing dementia later in life, people who get vaccinated have been shown to have a lower chance in the development of Alzheimer’s disease later on in their lives. This means that while prescription drugs have been shown to create symptoms such as memory loss, depression and fatigue, these symptoms are merely the side effects of these drugs and not necessarily due to dementia or Alzheimer’s. ---------------------------------------------------------------------------------------- Subscribe to Bestie : https://goo.gl/tUqro6 ---------------------------------------------------------------------------------------- Our Social Media: Facebook: https://www.facebook.com/bestieinc/ ----------------------------------------------------------------------------------------
Views: 419540 Bestie
Testing Cheap Drugstore Hair Products To Find The BEST | Dove, Axe, Old Spice, Got2B, American Crew
 
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25% Off Discount Code: HIGHQUALITY25 http://peteandpedro.com Pete & Pedro Putty (Award Winning): https://peteandpedro.com/product/putty/ American Crew Fiber: http://amzn.to/2ukK17i Old Spice Putty: http://amzn.to/2veUkWY Axe: http://amzn.to/2sRU7s9 Enter Code: STAYHANDSOME25 For 25% Off First Box http://www.tiege.com Check out my NEW website: http://www.alpham.com The BEST Hair Styling Products http://www.peteandpedro.com Check Out My Favorite Product The Fashion Anchor http://www.fashionanchor.com All Things Alpha M. http://www.alpham.com Pete & Pedro: http://www.peteandpedro.com My Website: http://www.iamalpham.com My Services and Products: http://www.aaronmarino.com Best Hair Product: http://www.peteandpedro.com Tiege Hanley Skin Care: http://www.tiege.com All promotion and advertising inquiries: [email protected] Alpha M. App: http://www.alphamapp.com/ Best Hair Product: http://www.peteandpedro.com Free Hairstyle E-Book: http://www.iamalpham.com/ezine FaceBook: https://www.facebook.com/IAmAlphaM Twitter: https://twitter.com/IAmAlphaM Instagram: https://www.instagram.com/aaronmarino/ My Businesses: http://www.alpham.com Alpha M. Consulting: http://www.aaronmarino.com i am alpha m: http://www.iamalpham.com Pete & Pedro: http://www.peteandpedro.com MENfluential Media: http://www.menfluential.com StyleCon: http://www.mensstylecon.com Alpha is amazed at the men's hair product drugstore options. In this video men's style, grooming, fitness and lifestyle expert, Aaron Marino of IAmAlphaM, AaronMarino, and Pete & Pedro is buying and testing drugstore hair products. He's heading to Walgreens for alternatives to Pete and Pedro Putty. With fresh clean hair, Alpha tries each of the 5 hair products: 1. American Crew Fiber ($19.00) - the price is the same as Pete and Pedro Putty and the most expensive of these 5 products. It's fresh smelling, a bit of shine, and hold is decent although he feels it will go flat as soon as he goes outside. Overall, it remains a great product. 2. Axe Spiked Up ($9.50) - it's super messy, sticky, and paste-like. It has the highest hold of all 5 products. After styling, his hair feels dry with a waxy residue. Note that after he washed his hair, he can still smell the Axe. The scent is intense. 3. Old Spice Putty ($8.00) - smells mild and is really soft. The more you heat it up, the scent becomes stronger (and not to Alpha's liking in regard to the fragrance). The product goes into his hair easier than Axe but has a much lower hold than American Crew and Axe. 4. Dove Sculpting Paste ($7.75) - mild fragrance, stiff, and emulsifies easily. The hold is not great (it's medium; not as good as the Axe) but on-par with American Crew (and half the price of American Crew). Overall, this product was Alpha's favorite of all 5 tested. 5. Got2B Glued Spiking Wax ($7.00) - a higher hold with a mild scent and similar in consistency to Dove. It's very sticky, heavy, and waxy. This product is the least favorite in terms of performance. Overall Thoughts If you put any of these products in wet hair and let air dry, they'll lock it down. A cost effective and good product is the Dove Sculpting Paste. American Crew is really good too. The other three are decent, but the lower price equates to lower quality ingredients. Note that Alpha prefers Pete and Pedro Putty above all of these products and would spend the extra bucks on the hair he cherishes. Additionally, unlike other brands where one product is good, the entire line Pete and Pedro line is superior with super high quality.
Views: 1964210 alpha m.
'Quality Assurance' Vs "Quality Control' .सिर्फ 10 मिनट में सीखें (हिंदी)
 
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In just 10 minutes understand difference between 'Quality Assurance' Vs "Quality Control . सिर्फ 10 मिनट में सीखें (हिंदी) Explained difference in 9 categories. Watch other videos from ‘Quality HUB India’- https://www.youtube.com/channel/UCdDEcmELwWVr_77GpqldKmg/videos • Subscribe to my channel ‘Quality HUB India’ for getting notification. • Like, comment & Share the video with your colleague and friends Link to buy My books 1. Mistake-Proofing Simplified: An Indian Perspective: https://www.amazon.in/gp/product/8174890165/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=8174890165&linkCode=as2&tag=qhi-21 2. Management Thoughts on Quality for Every Manager: https://www.amazon.in/gp/product/B0075MCLTO/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B0075MCLTO&linkCode=as2&tag=qhi-21 Gadgets I use and Link to buy 1. OnePlus 5 - Mobile https://www.amazon.in/gp/product/B01MXZW51M/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B01MXZW51M&linkCode=as2&tag=qhi-21 2. HP 14-AM122TU 14-inch Laptop https://www.amazon.in/gp/product/B06ZYLLT8G/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B06ZYLLT8G&linkCode=as2&tag=qhi-21 3. Canon EOS 700D 18MP Digital SLR Camera https://www.amazon.in/gp/product/B00VT61IKA/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B00VT61IKA&linkCode=as2&tag=qhi-21 4. Sonia 9 Feet Light Stand LS-250 https://www.amazon.in/gp/product/B01K7SW2OQ/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B01K7SW2OQ&linkCode=as2&tag=qhi-21 5. Sony MDR-XB450 On-Ear EXTRA BASS Headphones https://www.amazon.in/gp/product/B00NFJGUPW/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B00NFJGUPW&linkCode=as2&tag=qhi-21 6. QHM 602 USB MINI SPEAKER https://www.amazon.in/gp/product/B00L393EXC/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B00L393EXC&linkCode=as2&tag=qhi-21 7. Photron Tripod Stedy 400 with 4.5 Feet Pan Head https://www.amazon.in/gp/product/B00UBUMCNW/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B00UBUMCNW&linkCode=as2&tag=qhi-21 8. Tie Clip Collar mic Lapel https://www.amazon.in/gp/product/B00ITOD6NM/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B00ITOD6NM&linkCode=as2&tag=qhi-21 9. Hanumex Generic Green BackDrop Background 8x12 Ft for Studio Backdrop https://www.amazon.in/gp/product/B06W53TMDR/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B06W53TMDR&linkCode=as2&tag=qhi-21 10. J 228 Mini Tripod Mount + Action Camera Holder Clip Desktop Self-Tripod For Camera https://www.amazon.in/gp/product/B072JXX9DB/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B072JXX9DB&linkCode=as2&tag=qhi-21 11. Seagate Backup Plus Slim 1TB Portable External Hard Drive https://www.amazon.in/gp/product/B00GASLJK6/ref=as_li_tl?ie=UTF8&camp=3638&creative=24630&creativeASIN=B00GASLJK6&linkCode=as2&tag=qhi-21 Watch other Videos from ‘Quality HUB India’ 1. Process Capability Study (Cp,Cpk, Pp & Ppk) - https://www.youtube.com/watch?v=5hBRE0uji5w 2. What is Six Sigma ?Learn Six Sigma in 30 minutes- https://www.youtube.com/watch?v=1oiKYydbrSw 3. Failure Mode and Effects Analysis (FMEA) - https://www.youtube.com/watch?v=UxSBUHgb1V0&t=25s 4. Statistical Process Control (SPC) in Hindi – https://www.youtube.com/watch?v=WiVjjoeIrmc&t=115s 5. Measurement System Analysis (MSA) (Part 1) - https://www.youtube.com/watch?v=GGwaZeMmZS8&t=25s 6. Advanced Product Quality Planning(APQP) - https://www.youtube.com/watch?v=FaawYoPsUYE&t=35s 7. ‘Quality Circles' - https://www.youtube.com/watch?v=kRp9OIANgG8&t=25s 8. What is 'Cost of Quality' and 'Cost of Poor Quality' - https://www.youtube.com/watch?v=IsCRylbHni0&t=25s 9. How to perfectly define a problem ? 5W and 1H approach - https://www.youtube.com/watch?v=JXecodDxBfs&t=55s 10. What is 'Lean Six Sigma' ? Learn the methodology with benefits. - https://www.youtube.com/watch?v=86XJqf1IhQM&t=41s 11. What is KAIZEN ? 7 deadly Waste (MUDA) and benefit of KAIZEN - https://www.youtube.com/watch?v=TEcE-cKk1qI&t=115s 12. What is '5S' Methodology? (Hindi)- https://www.youtube.com/watch?v=dW8faNOX91M&t=25s 13. 7 Quality Control Tools - (Part 1) Hindi - https://www.youtube.com/watch?v=bQ9t3zoM0NQ&t=88s 14. "KAIZEN" in HINDI- https://www.youtube.com/watch?v=xJpbHTc3wmo&t=25s 15. 'PDCA' or 'Deming Cycle'. Plan-DO-Check-Act cycle - https://www.youtube.com/watch?v=Kf-ax6qIPVc 16. Overall Equipment Effectiveness (OEE) - https://www.youtube.com/watch?v=5OM5-3WVtd0&feature=youtu.be 17. Why-Why Analysis? - Root Cause Analysis Tool - https://www.youtube.com/watch?v=Uxn6N6OJvwA
Views: 485214 Quality HUB India
Manufacturing Drugs at Large Scale
 
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Discover how Biogen Idec's industry-recognized expertise in manufacturing biologic therapies blends a combination of innovation and collaboration to ensure quality and reliable drugs.
Views: 43301 Biogen
Colombia's Hidden Cocaine Route: El Naya
 
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Colombia is one of the world's top cocaine-producing countries with a majority of the drug ending up on US soil. VICE Colombia take a dangerous trip along El Naya to examine the grueling production process. Click here to subscribe to VICE: http://bit.ly/Subscribe-to-VICE Check out our full video catalog: http://bit.ly/VICE-Videos Videos, daily editorial and more: http://vice.com More videos from the VICE network: https://www.fb.com/vicevideo Like VICE on Facebook: http://fb.com/vice Follow VICE on Twitter: http://twitter.com/vice Read our Tumblr: http://vicemag.tumblr.com Follow us on Instagram: http://instagram.com/vice Check out our Pinterest: https://pinterest.com/vicemag Download VICE on iOS: http://apple.co/28Vgmqz Download VICE on Android: http://bit.ly/28S8Et0
Views: 1669080 VICE
A Holistic approach of QbD in Pharmaceutical Industry
 
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Quality by design (QbD) is an approach for process development to ensure the patients’ needs and product performance by which quality is not just tested in the final drug substance but is built within the process. (Process) A systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quality risk management. (Science) The prime aim of the QbD is to achieve the right quality product by right first time (Business) Facilitate continuous improvement with a reduced need for post-approval changes. (Regulatory)
BEST Cheap Drugstore Skin Care Products For MEN!
 
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Use Code: JUSTBETTER25 for 25% off Your 1st Tiege Kit: https://tiege.com/justbetter25 BEST hair product in the universe (imo) P&P http://peteandpedro.com use code: BESTHAIR25 for 25% off your ENTIRE order! https://peteandpedro.com/collections/bueno_hair_products/products/salt Putty: https://peteandpedro.com/collections/bueno_hair_products/products/putty All promotion and advertising inquiries: [email protected] Check out my NEW website: http://www.alpham.com The BEST Hair Styling Products http://www.peteandpedro.com All Things Alpha M. http://www.alpham.com Pete & Pedro: http://www.peteandpedro.com My Website: http://www.iamalpham.com My Services and Products: http://www.aaronmarino.com Best Hair Product: http://www.peteandpedro.com Tiege Hanley Skin Care: http://www.tiege.com Best Grooming Tool: http://bit.ly/2tiyTXO Alpha M. App: http://www.alphamapp.com/ Best Hair Product: http://www.peteandpedro.com Free Hairstyle E-Book: http://www.iamalpham.com/ezine FaceBook: https://www.facebook.com/IAmAlphaM Twitter: https://twitter.com/IAmAlphaM Instagram: https://www.instagram.com/aaronmarino/ My Businesses: http://www.alpham.com Alpha M. Consulting: http://www.aaronmarino.com i am alpha m: http://www.iamalpham.com Pete & Pedro: http://www.peteandpedro.com MENfluential Media: http://www.menfluential.com MENfluential Conference: http://menfluentialconference.com/ Tiege Hanley: http://tiege.com You've probably heard of Alpha's skin care company, Tiege Hanley, that he started 2 years ago. The company's goal is to 'uncomplicate' the process of looking incredible by providing a simplified skin care solution. Men need 'easy' at an awesome price, and Tiege Hanley gives men what they need. Ultimately, Tiege Hanley will make you look incredible and feel confident. In this video men's style, grooming, fitness and lifestyle expert, Aaron Marino of IAmAlphaM, AaronMarino, and Pete & Pedro says that Tiege Hanley cut out the middle man to cut the price and provides simple instructions with each kit. A lot of guys don't want to try Tiege Hanley for whatever reason. And Alpha wouldn't be doing his job as an advisor if he didn't explore other options and didn't let you know what the alternatives are - so he's been experimenting with drug store products. The drug store versions that are the best as a result of Alpha's testing: Face wash - Men's Dove + Care Face Wash: nice product that's mild in terms of the scent, it foams but not too sudsy. It doesn't leave your face too dry. It's $5 for 5 ounces. Exfoliating Scrub - Burt's Bees Deep Pore Scrub: use peach or apricot seeds (big pieces) as the exfoliator, it's unscented, and it washes off cleaner. $10 was the cost. AM Moisturizer - Keep in mind that an AM moisturizer contains an SPF. Alpha itemizes the products he didn't like and why. But the winner for this category was Neutrogena Age Fighter. This stuff was $13 for 1.4 ounces, SPF 15, and with no scent. PM Moisturizer - Not many men's night creams are on the market in drug store brands. Burt's Bees Intense Hydration is thick with a neutral scent. The price is $10. Eye Cream - This product is essential to fight crows feet and dark circles. Alpha chose Oil of Olay Regenerist, which is a superior product. The cost $50 for .5 ounce. Anti-aging Serum - This product fights wrinkles with retinol. Neutrogena Rapid Wrinkle Repair is Alpha's choice for this category. The cost is $22. Your drug store kit would be $105. The higher end products at Ulta and Sephora are better quality than drug store, but the kit would come up to $200+. The Tiege Hanley system is a fraction of the cost (L1 $25, L2 $35, L3 $45) and will last a month. It's totally customizable, crazy affordable, and quality. It's all that you need. As a result, Alpha had a tough time being objective. Regardless of what products you chose to use, take care of your handsome face! Use Code: JUSTBETTER25 for 25% off Your 1st Tiege Kit: https://tiege.com/justbetter25
Views: 554696 alpha m.
Avoiding Potholes in Process Development Part IV: Safety Testing for Drug Products
 
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Regis Technologies hosted a seminar with guest speaker Neal G. Anderson, Ph.D., on Avoiding Potholes in Process Chemistry. This talk discussed how to anticipate and avoid problems in process development. This fourth installment of the five videos covers FDA requirements, potential genotoxic impurities, and toxicity. A full abstract follows: The first questions that a scale-up organization asks are: How much material is needed? How soon? For what purpose? All processes are developed to be fit-for-purpose, with different requirements at different stages of development. Safe operating conditions must be identified for effective scale-up; perhaps continuous flow chemistry offers advantages, or the chemistry could be outsourced to CROs that specialize in handling energetic chemistry. Mass transfer, heat transfer, and extended operating times can impact scale-up. Workups must be designed to thoroughly quench reagents and ideally deliver the product without decomposition. For early Phase studies products can be purified by chromatography, later perhaps by extraction and crystallization. The stability of intermediates can pose problems. Thorough analytical investigations are justified to unambiguously identify compounds. Screening for the optimal final form should be carried out early, unless the product is an oil or a lyophile. Structurally related impurities, potentially mutagenic impurities, and residual elemental metals must be controlled. As a compound progresses towards commercialization processes are developed to be more cost-effective.
Drug Product Development and Manufacturing
 
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CoreRx’s experienced scientists and pharmaceutical professionals lend their expertise to produce safe, effective, and innovative drug products. We offer analytical labs, formulation suites, manufacturing facilities, as well as cGMP warehousing, ensuring quality control of all the services we offer. Please call us at 727-259-6950 for more details. CoreRx Pharma 14205 Myerlake Circle Clearwater, FL, 33760 Tel Number: 727-259-6950 Toll Free Number: 877-461-4448 Fax Number: 727-259-6971 Email: [email protected]
Views: 43 CoreRx Pharma
Top 200 Drugs Pronunciation (Generic names/ Brand names)
 
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Top 200 drugs pronunciation: 1. Analgesics 0:03 2. Anti-infectives 1:55 3. Cardiovascular 3:42 4. CNS 7:59 5. Endocrine 12:56 6. Gastrointestinal 15:17 7. Miscellaneous 16:33 8. Respiratory 17:23
Views: 218467 Vince Li
bozoomer GMP (Good Manufacturing Practice) - Michael DuBay
 
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bozoomer GMP Certification - Good Manufacturing Practice Good manufacturing practice guidelines provide guidance for manufacturing, testing, and quality assurance in order to ensure that a drug product is safe for human consumption. Many countries have legislated that pharmaceutical and medical device manufacturers follow GMP procedures and create their own GMP guidelines that correspond with their legislation. All guidelines follow a few basic principles: Hygiene: Pharmaceutical manufacturing facility must maintain a clean and hygienic manufacturing area. Controlled environmental conditions in order to prevent cross contamination of drug product from other drug or extraneous particulate matter which may render the drug product unsafe for human consumption. Manufacturing processes are clearly defined and controlled. All critical processes are validated to ensure consistency and compliance with specifications. Manufacturing processes are controlled, and any changes to the process are evaluated. Changes that have an impact on the quality of the drug are validated as necessary. Instructions and procedures are written in clear and unambiguous language. (Good Documentation Practices) Operators are trained to carry out and document procedures. Records are made, manually or by instruments, during manufacture that demonstrate that all the steps required by the defined procedures and instructions were in fact taken and that the quantity and quality of the drug was as expected. Deviations are investigated and documented. Records of manufacture (including distribution) that enable the complete history of a batch to be traced are retained in a comprehensible and accessible form. The distribution of the drugs minimizes any risk to their quality. A system is available for recalling any batch of drug from sale or supply. Complaints about marketed drugs are examined, the causes of quality defects are investigated, and appropriate measures are taken with respect to the defective drugs and to prevent recurrence. Practices are recommended with the goal of safeguarding the health of patients as well as producing good quality medicine, medical devices, or active pharmaceutical products. In the United States, a drug may be deemed "adulterated" if it has passed all of the specifications tests, but is found to be manufactured in a facility or condition which violates or does not comply with current good manufacturing guideline. Therefore, complying with GMP is mandatory in pharmaceutical manufacturing. GMP guidelines are not prescriptive instructions on how to manufacture products. They are a series of general principles that must be observed during manufacturing. When a company is setting up its quality program and manufacturing process, there may be many ways it can fulfill GMP requirements. It is the company's responsibility to determine the most effective and efficient quality process.
Views: 2603 Michael Dubay
Inside Crystal Meth Lab | Narco State | Sky News
 
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In Mexico, drug cartels control the production of crystal meth on an industrial scale. We visit a secret lab to see how the product is cooked. This report by Sky's Stuart Ramsay is part of our Narco State series. Watch more videos at http://bit.ly/1G8ETNe. SUBSCRIBE to our YouTube channel for more great videos: http://www.youtube.com/skynews Follow us on Twitter: https://twitter.com/skynews and https://twitter.com/skynewsbreak Like us on Facebook: https://www.facebook.com/skynews For more great content go to http://news.sky.com and download our apps: iPad https://itunes.apple.com/gb/app/Sky-News-for-iPad/id422583124 iPhone https://itunes.apple.com/gb/app/sky-news/id316391924?mt=8 Android https://play.google.com/store/apps/details?id=com.bskyb.skynews.android&hl=en_GB
Views: 215204 Sky News
Trauma and Addiction: Crash Course Psychology #31
 
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Want more videos about psychology every Monday and Thursday? Check out our sister channel SciShow Psych at https://www.youtube.com/scishowpsych! *** So, what do Batman and J.R.R. Tolkien have in common? Post Traumatic Stress Disorder. It used to be called "Shellshock" and it can be really really really destructive. In this episode of Crash Course Psychology, Hank lays out the low down on PTSD and how trauma can affect the brain. Plus, a look at how addiction can play into trauma and the different types of treatments used to help those afflicted. -- Table of Contents: PTSD: Causes and Symptoms 01:57:18 How Trauma Can Affect the Brain 05:12:09 Addiction 07:08:18 Trauma and Addiction 07:41:17 Dual Treatment Model 08:24:07 Post-Traumatic Growth 06:31:00 The Wise Frodo Baggins 00:00 -- Want to find Crash Course elsewhere on the internet? Facebook - http://www.facebook.com/YouTubeCrashCourse Twitter - http://www.twitter.com/TheCrashCourse Tumblr - http://thecrashcourse.tumblr.com Support CrashCourse on Subbable: http://subbable.com/crashcourse
Views: 1648763 CrashCourse
Ifotam Co. Ltd. - active pharmaceutical ingredients
 
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Ifotam -- Clever synthesis for demanding pharmacy. Ifotam CO.Ltd is one of the first spin off type companies in Poland, created on the basis of knowledge and experience of the research staff of the Center of Molecular and Macromolecular Studies (Polish Academy of Sciences, Lodz) and the Pharmaceutical Institute (Warsaw). The company was founded in 1989. Our activities are focused on search for, and development of, new methods of synthesis, transfer of technologies, production of APIs and sales of pharmaceutical substances. Many years of work on the company development have resulted in our current position of the one of more important manufacturers of first generation cytostatics in Europe. We specialize in synthesis of three groups of pharmaceuticals: - drugs used in anticancer therapies, - drugs used in treatment of skeletal system disorders, - protective drugs -- used in antitumor chemotherapy. On request of our clients, we also perform custom syntheses. Two production sites located in Łódź, with their laboratory and production facilities, allow to manufacture active pharmaceutical ingredients in quantities ranging from a few grams to 2 tonnes. Ifotam has at its disposal own, modern research and development laboratories, which enable us to launch new products efficiently, effectively and in a short time. Our highly qualified R&D Department staff makes it possible to develop new ideas as well as to search for, and to implement innovative solutions. That dynamically developing department of our company can take pride in numerous achievements and patents in the field of chemical synthesis, which have contributed to high quality and efficiency of our products. Ifotam has been also cooperating for many years with scientific institutions and research centers all over the world, which enables quick implementation of the latest advances in production of APIs. The products manufactured by Ifotam meet the requirements of current GMP. Owing to precise implementation of, and strict compliance with the GMP requirements, we gained the approval of FDA as early as 2001. We were one of the first companies in Poland positively assessed by international auditors. The active substances are manufactured in production centers specially designed for this purpose. Each substance is manufactured in the dedicated premises and the dedicated apparatus is used. High quality of our products, maintained consistently over a period of 20 years, is our asset. Our Quality Control Laboratory is responsible for monitoring the quality of products sold by us. The substrates using in the manufacturing processes, intermediates and final products are controlled there. All the procedures and instructions are based on the GMP guidelines. The Laboratory has analytical equipment allowing to perform all analyses in compliance with the Polish, European and US Pharmacopoeias. Ifotam is associated, first of all, with innovation, quality and timely delivery of products. We are a dynamically developing Polish enterprise supplying pharmaceutical companies all over the world. It is confirmed by the fact that export accounts for as much as 80% of our sales. We care about the satisfaction of our clients on such demanding markets as the USA, Germany, or Russia. Our partners have been cooperating with us with satisfaction for over 10 years. We supply products meeting the strict standards of the pharmaceutical market. Our products are: ifosfamide, cyclophosphamide, zoledronic acid, pamidronate disodium, risedronate sodium and others.
Views: 15249 Ifotam Co. Ltd.
The iPhone XR Drop Test...I Didn’t Expect This
 
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I had to drop test the new iPhone XR vs iPhone XS Max to see how a durability test would go! The aluminum build on the XR vs the steel on the XS makes both flagship smartphones weird. For $750 the iPhone XR is cheaper but I didn’t expect this to happen… ➽Subscribe if you’re new!! ➽ http://bit.ly/SubTechSmartt TechSmartt Merch ➽ http://bit.ly/TechSmarttMerch iPhone XR: https://ebay.to/2JsuKpS IPhone XS Max: https://ebay.to/2F070dQ IPhone XS: https://ebay.to/2ObZmMV The iPhone XR has an all-screen LCD 6.1-inch liquid retina display, with multi-touch technology and an IP67 water resistant rating. The XR uses an A12 Bionic chip to take photos with the 12MP wide-angle rear camera, which shoots at f/1.8 aperture. It has optical stabilization, a digital zoom of up to 5x and a more advanced Portrait mode with bokeh and depth control, along with portrait lighting effects! The battery lasts up to 1.5 hours longer than the iPhone 8 Plus, so the upgrade is definitely worth it. The iPhone XR is running iOS 12, and comes in Product RED, Yellow, White, Coral, Black, and Blue. DON'T Buy The iPhone XS Max https://www.youtube.com/watch?v=_4Ye2... Huge iPhone XS Max Gold Giveaway - 3 Million Subscriber Special https://www.youtube.com/watch?v=Q-q4B... Ultimate iPhone XS Max Water Test - Secretly NOT Waterproof? https://www.youtube.com/watch?v=d04u9... iPhone XS vs iPhone XS Max - Ultimate Drop Test! https://www.youtube.com/watch?v=KFbvM... Apple iPhone XS/XS Max Playlist https://www.youtube.com/playlist?list... iPhone XS vs XS Max - Which To Buy? https://www.youtube.com/watch?v=w1Cjv... iPhone XR...Why I’m Waiting https://www.youtube.com/watch?v=1BW1V... Thanks for watching! #iPhoneXR #TechSmartt #iPhoneXRDropTest PB JAMS 🎧🎶https://open.spotify.com/user/keatonkeller/playlist/4gjZztCG5M93eC11Rond9z?si=NCy7uz6rT6CXUPr-myW9Qg comment ‘it got DROPPED" if u see this 🤣 MORE TECHSMARTT VIDS: iPhone XR...Why I’m Waiting ➡ https://www.youtube.com/watch?v=1BW1V1avDpo&index=16&list=PLPCx-1KKqYKwyHTeXOWSVeD2SwL1ZUwDs&t= iPhone XS vs XS Max - Which To Buy? ➡ https://www.youtube.com/watch?v=w1Cjv_I_m2Y&index=9&list=PLPCx-1KKqYKzbzHM5yGJq6qz1Ws1UB8tM&t=2s Twitter ➽ http://twitter.com/techsmartt Instagram ➽ http://instagram.com/techsmartt Facebook ➽ http://facebook.com/techsmarttyt Snapchat ➽ http://snpcht.me/keaton Our Equipment: https://www.bhphotovideo.com/c/product/1340800-REG/canon_2215c002_eos_c200_ef_camera.html https://www.bhphotovideo.com/c/product/1274705-REG/canon_eos_5d_mark_iv.html https://www.bhphotovideo.com/c/product/843008-USA/Canon_5175B002_EF_24_70mm_f_2_8L_II.html https://www.bhphotovideo.com/c/product/1009419-REG/canon_5260b054_eos_5d_mark_iii.html https://www.bhphotovideo.com/c/product/878340-REG/Sennheiser_MKE_600_Shotgun.html https://www.bhphotovideo.com/c/product/647011-USA/Canon_3554B002_EF_100mm_f_2_8L_Macro.html https://www.bhphotovideo.com/c/product/1051475-USA/canon_9518b002_ef_16_35mm_f_4l_is.html ——— TechSmartt is a kid & family friendly channel, where I unbox and review cool tech & gadgets from the internet!
Views: 3015168 TechSmartt
ICH - Q7 GMPs for APIs - Section 3 of 6
 
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Seminar titled, "Global Trends in API and Drug Product GMPs", by Michael Anisfeld, Globepharm Consulting, September, 2014 at Regis Technologies Inc., Morton Grove, IL. www.registech.com
Everything you think you know about addiction is wrong | Johann Hari
 
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What really causes addiction — to everything from cocaine to smart-phones? And how can we overcome it? Johann Hari has seen our current methods fail firsthand, as he has watched loved ones struggle to manage their addictions. He started to wonder why we treat addicts the way we do — and if there might be a better way. As he shares in this deeply personal talk, his questions took him around the world, and unearthed some surprising and hopeful ways of thinking about an age-old problem. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more. Find closed captions and translated subtitles in many languages at http://www.ted.com/translate Follow TED news on Twitter: http://www.twitter.com/tednews Like TED on Facebook: https://www.facebook.com/TED Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
Views: 5645062 TED
webinar recording - pre filled syringe lubrication control
 
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With my examples I will discuss the relation between the siliconization profiles measured with the LE and the performance of the final drug product. As we see in many examples, silicone oil once applied forms not a static but a rather dynamic layer. Re-distribution of silicone by gravity can be observed. Therefore the age of a syringe really matters as well as other storage conditions. Interaction with the drug also affects the layer and changes its uniformity and therefore the performance of the device. This is well known for spray-on siliconized syringes, but also an important quality factor baked-on cartridges. We will share examples from: Primary packaging control - PFS Stability, thickness and distribution Bulk process siliconization (baked-on) quality control and formulation interaction Pharmaceutical Manufacturing in primary packaging control
Taking control of sustained drug release - with Parteck® SRP 80
 
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Solid oral formulations are some of the most well established dosage forms. In many cases, long-acting efficacy of the API is required. Parteck® SRP 80 is a highly functional excipient that offers superior reliability and consistency in sustained-release products. This animation provides an overview on how Parteck® SRP 80 works in sustained-release formulations. Get Connected! Join MilliporeSigma on your favorite social media outlet for the latest updates, news, products, innovations, and contests! Learn more about recent developments in oral sustained release formulations in this webinar: www.emdmillipore.com/sustainedrelease-webinar Learn more about Parteck® SRP 80: www.emdmillipore.com/partecksrp80 Learn more about our offering of functional excipients: www.emdmillipore.com/parteck Join us on LinkedIn: https://goo.gl/SSrNf2 Join the community on twitter: https://twitter.com/milliporesigma Do not forget to subscribe to have better access to our videos!
How I Cleared My Acne | My Drugstore Skincare Routine 2017
 
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This was probably my most highly requested video ever and is a bit more personal than usual. Here's details about my struggle with acne and my current drugstore morning skincare routine and evening drugstore skincare routine! Time Stamps: Evening Routine: 3:38 Morning Routine: 12:16 Like & Subscribe! http://bit.ly/2cvQioK MY FILMING SETUP Camera: http://amzn.to/2llZUWg Tripod: http://amzn.to/2kC3F5t Lights: http://amzn.to/2kNx7X0 Microphone: http://amzn.to/2kuen2N CONNECT WITH ME Subscribe to this channel: http://bit.ly/2cvQioK Instagram: https://www.instagram.com/drugstoremaven/ Twitter: https://twitter.com/DrugstoreMaven Snapchat: drugstoremaven PRODUCTS MENTIONED Neutrogena Makeup Wipes http://rstyle.me/~9ZNDe Neutrogena Oil Free Eye Makeup Remover http://rstyle.me/~9ZNDj Gly/Sal Wash (from my dermatologist) - Similar option: https://goo.gl/XYrmfH CeraVe Foaming Facial Cleanser http://rstyle.me/~9ZNDm Veltin - prescription Retin-A Organic Cold Pressed Rose Hip Seed Oil https://goo.gl/vm73Ee CeraVe Skin Renewing Night Cream http://rstyle.me/~9ZNGV The Ordinary Natural Moisturizing Factors +HA https://goo.gl/D7Q9Z1 Neutrogena Hydro Boost Gel Eye Cream http://rstyle.me/~9ZNGB Yes to Cucumbers Eye Cream http://rstyle.me/~9ZNGH Vaseline Cetaphil Gentle Skin Cleanser http://rstyle.me/~9ZNIM Ascorbyl Glucoside Solution 12% https://goo.gl/xgKtt2 Bare Republic Mineral Sunscreen Face Lotion https://goo.gl/wQhixE RELEVANT VIDEOS Liah Yoo: https://goo.gl/WMeoPq (Time Stamp 0:45 and 6:36) Gothamista: https://goo.gl/RQjS5p (Time Stamp 1:56) WHAT IM WEARING Almay Skin Clearing Foundation Maybelline Fit Me Concealer Rimmel Stay Matte Powder Catrice Contour and Highlight elf Cream Blush Physician's Formula Eyeliner Essence Lash Princess Mascara elf Lip Laquer (Praline) Nails: Wet n Wild Heatwave This video is not sponsored. Some links are affiliate and I receive a small commission if you choose to purchase via that link. As always, ALL opinions are my own. SHADE COMPARISON Maybelline Fit Me 128 L'Oreal Stay Matte 105 Maybelline Better Skin 30 L'Oreal True Match W4
Views: 80211 Drugstore Maven
Annual Product Reviews  New FDA Quality Metrics Guidance on Annual Product Review
 
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Click here for more Information:-http://bit.ly/2pikM0y A review, conducted annually to give an organized and comprehensive summary of all production activities, analytical and physical, Stability, Deviations, Change controls, Out of specifications recalls and market complaints, which assess the quality standards of each drug product. ▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀ Subscribe on Youtube:http://bit.ly/2oSHP1I Follow us on Facebook:https://www.facebook.com/fdaeducator/ Follow us on Twitter:https://twitter.com/FDAEducator Follow us on Google+:-http://bit.ly/2FY0GCX ▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀▄▀
Views: 201 FDA Educator
National Drug Control Strategy
 
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The Drug Czar unveiling the new National Drug Control Policy. National Drug Control Strategy - 1990-04-27 - Product 11933-1-DVD - House Committee Government Reform and Oversight. Subcommittee on Legislation and National Security. The subcommittee heard. Obama releases 2017 National Drug Control Strategy; Kevin Sabet vs. Ethan Nadelmann on MSNBC; Todds Toker Topic on Product Quality; music by Wallpaper. Synthetic Drug Control Strategy - House Oversight Committee - 2006-06-16 - Product 193025-1-DVD - House Committee on Government Reform and Oversight. Subcommittee on Criminal Justice, Drug.
Views: 3 Oda Dodgen
Stability Indicating Methods
 
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A Stability Indicating Method (SIM) is defined as a validated analytical procedure that accurately and precisely measures active ingredients (drug substance or drug product) free from process impurities, excipients and degradation products. SIMs must be validated for the specific formulation being tested. The SIM is used to perform the assay (test) and ultimately extend the beyond use date. This session will illustrate how SIM are performed and include specific examples for quantitative assays. A comparison of stability indicating methods and release methods will be presented for sterile and non-sterile products. Participants will gather an understanding of the basic process for developing and validating SIM. Learning Objectives: At the conclusion of the program, the participants should be able to: (1) Define a stability indicating method. (2) Explain how a stability indicating method is different than a release (or potency) method. (3) Describe the process for developing and validating a stability indicating method.
Views: 565 ARL BioPharma
Free Webinar - Defining a Strategy for the Validation and Qualification of Sterile Filtration...
 
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" Investigational New Drug (IND) applications must contain information allowing an assessment of whether or not the product is reasonably safe for initial testing in humans. This typically includes information pertaining to the chemical composition, manufacturing methods, stability, and controls used for manufacturing the drug substance and the drug product. Providing this information for investigational medicines can be more complex where the manufacturing process may not yet be fully defined. Sterilizing filtration should be qualified during early clinical phases to demonstrate that it is effectively providing a sterile product without adversely affecting its properties. The filter, as critical equipment used for manufacturing sterile phase 1 investigational drug, should not contaminate or otherwise react with, add to, or be absorbed by the drug. In order to assess its performance and thereby ensure the quality of the product, several aspects have to be examined including bacterial retention, chemical compatibility, extractables and adsorption. Based on our experience at Merck Millipore, you will learn about the key elements of sterile filtration validation, along with understanding more about global regulatory guidance for developmental phase drug products." Watch the full webinar here: https://goo.gl/HVJiqC Recorded: February, 2015
Project – Drug Traceability and Control in Pharmaceuticals Industry (AGP13304) - Setup Demo Video
 
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Project – Drug Traceability and Control in Pharmaceuticals Industry (Blockchain, C#, ASP.NET Core 2) Get This Project Here: https://adrusyaglobal.com/product/project-drug-traceability-and-control-in-pharmaceuticals-industry-blockchain-csharp-asp-net-core-2/ Get More Software Projects Here: https://adrusyaglobal.com/getprojects/
Views: 1 ADRUSYA GLOBAL